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The basis of the whole doctrine of the Buddha is that whatever is transitory is subject to cessation, to changeableness, to pain and to suffering. Everything follows this law of impermanence and everything is subject to annihilation. The Buddha also showed that personality, and every part of it, is subject to decay and dissolution, and is therefore always painful.
-- Notebooks Category 15: The Orient > Chapter 2 : India Part 1 > # 309