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In the horoscopes of ordinary people, in which a concatenation of several planets called the Gurukula does not appear, the expert can with reasonable accuracy plot the course of their future life because their characters are not likely to change very much. But, in the horoscopes of those few people in which the Gurukula does appear, it is not possible to prognosticate the future. Usually such persons have a great mission to perform, whether public or hidden. The individual karma from past lifetimes, even of the present one, may be changed during the fulfilment of such a mission. Ramana Maharshi had the Gurukula in his chart, as did Gandhi, and all Masters have it.

Philosophy agrees that karma can be changed, modified or counteracted for the most part, but there are certain limits beyond which one cannot go.

-- Notebooks Category 9: From Birth to Rebirth > Chapter 3 : Laws and Patterns of Experience > # 454